Indole 3 Carbinol Indole-3-carbinol may have cancer chemopreventive activity. Glucosinolates themselves have minimal anticancer activity. Indole-3-carbinol is produced from indole-3-glucosinolate via the action of the enzyme myrosinase (thioglucoside glucohydrolase), an enzyme which is present in cruciferous vegetables and activated upon maceration of the vegetables. Indole-3-carbinol is found in highest concentrations in broccoli, but is also found in other cruciferous vegetables, such as cauliflower, cabbage, and kale, supplements now available for those who don’t want to eat these vegetables.
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